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Filtered Search Results
Apexbio Technology LLC YC 1 170632-47-0 200mg
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YC-1 (CAS 170632-47-0) is a small molecule originally identified as an inhibitor of hypoxia-inducible factor-1 (HIF-1 ) a transcription factor that regulates genes involved in angiogenesis cell survival and tumor progression under hypoxic conditions YC-1 suppresses the transcriptional activity of HIF-1 with an IC50 of 1 2 M and inhibits HIF-1 expression at the post-transcriptional level in hypoxic hepatocellular carcinoma cell models In vivo YC-1 reduces tumor size and vascularization accompanied by decreased expression of HIF-1 and HIF-1-regulated genes YC-1 serves as a tool for investigating HIF-1 signaling pathways and their roles in cancer biology and hypoxia-associated diseases
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Medchemexpress LLC Insulin (human) | 11061-68-0 | 99.9% | 5807.57 | 200 MG
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Insulin (human) is a polypeptide hormone vital for regulating glucose levels in the body, primarily used in the treatment of diabetes mellitus. This product is a recombinant human insulin, a synthetic version of the hormone, and appears as a white to off-white solid. The human insulin gene contains specific intervening sequences, one within the 5'-untranslated segment of the mRNA and another interrupting the C-peptide encoding region, which are important for its biological function.
- Regulates glucose levels
- Used for diabetes mellitus treatment
- Recombinant human insulin
- White to off-white solid appearance
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Apexbio Technology LLC AZ5104 1421373-98-9 200mg
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AZ5104 (CAS 1421373-98-9) is a demethylated metabolite of AZD9291 functioning as a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase It exhibits high affinity for mutant EGFR forms with IC50 values below 1 nM for EGFR L858R/T790M 6 nM for EGFR L858R 1 nM for EGFR L861Q and 25 nM for wild-type EGFR Compared to AZD9291 AZ5104 demonstrates increased potency in cellular models harboring EGFR ex19del (PC-9) T790M (H1975) and wild-type EGFR (LOVO) In vivo oral administration in mice led to a plasma metabolite level of 33% at 3 hours post-dose and 5 mg/kg/day reduced tumor growth in relevant models AZ5104 serves as a valuable tool for studying EGFR-driven cancer mechanisms and resistance
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Apexbio Technology LLC SKF38393 HCl 62717-42-4 200mg
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SKF38393 HCl is a selective dopamine D1 receptor agonist exhibiting activity through direct binding and stimulation of D1 receptors Activation of D1 receptors primarily induces adenylyl cyclase stimulation and increases cAMP-dependent protein kinase signaling subsequently modulating neuronal differentiation growth and dopamine-mediated functional responses Experimental evidence indicates that SKF38393 administration impacts gene expression patterns related to dopamine receptor-sensitive neuronal pathways and neuropeptides Additionally in vitro studies report SKF38393 to inhibit proliferation of certain tumor cell lines exemplified by decreased cell growth in breast carcinoma-derived MCF-7 cells at submicromolar concentrations It is widely utilized as a pharmacological tool in neuroscience and oncology research
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000370629 SCH900776 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000370945 RIMEGEPANT 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000371277 GSK269962A 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000371376 POMALIDOMIDE-5-C9-NH 5MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000371628 AZD1208 200MG
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eMolecules 1216800-29-1 | METHYL 1,2,3,4-TETRAHYDROQUINOLINE-7-CARBOXYLATE HCL | MFCD09026783 | 1g
Ambeed | Fmoc-Asp(OtBu)-OL | 250mg | 490554662 | A328403 | 133565-45-4 | MFCD01861297 | 397.471 | C23H27NO5
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eMolecules 1379345-02-4 | 4-BROMO-8-NITROQUINOLINE | MFCD08688610 | 1g
Ambeed | Ethyl 2-amino-1-methyl-1H-imidazole-5-carboxylate | 250mg | 552662731 | A229412 | 177760-04-2 | MFCD09997799 | 169.184 | C7H11N3O2
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Medchemexpress LLC CP 339818 hydrochloride | 478341-55-8 | 99.6% | 340.89 g/mol | C21H25ClN2 | 5 MG
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CP 339818 hydrochloride is a small-molecule, non-peptide ion-channel inhibitor used in electrophysiology and pharmacology research. It blocks Kv1.3 and Kv1.4 channels and inhibits HCN channels, making it useful for studying Kv- and HCN-mediated currents and T-cell activation.
- Non-peptide Kv1.3 and Kv1.4 channel blocker.
- Inhibits HCN channel isoforms with micromolar potency.
- High-purity white to off-white solid suitable for research use.
- Soluble in DMSO up to 62.5 mg/mL.
- Store sealed at 4°C; in solution, keep at -80°C (up to 6 months) or -20°C (up to 1 month).
- Molecular weight 340.89 g/mol; formula C21H25ClN2.
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Medchemexpress LLC Quinidine methiodide | 42982-87-6 | C21H27IN2O2 | 5 MG
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Quinidine methiodide is a metabolite of Quinidine, which is known as an antiarrhythmic agent. This product appears as a solid with a white to light yellow color.
- Metabolite of Quinidine
- Antiarrhythmic agent
- Solid appearance
- White to light yellow color
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Medchemexpress LLC Quinidine (15% dihydroquinidine) | 56-54-2 | >98.36% | 10 G
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Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. It acts as a potent, orally active, and selective cytochrome P450db inhibitor. Additionally, Quinidine is a K+ channel blocker with an IC50 of 19.9 μM and is capable of inducing apoptosis. This compound can also be utilized for malaria research.
- Antiarrhythmic agent.
- Potent, orally active, selective cytochrome P450db inhibitor.
- K+ channel blocker with an IC50 of 19.9 μM.
- Can induce apoptosis.
- Used for malaria research.
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Apexbio Technology LLC Quinine HCl Dihydrate 6119-47-7 10g
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Quinine HCl Dihydrate is a quinoline alkaloid hydrochloride salt presented as a dihydrate form It exerts its biological activity primarily through interference with heme detoxification mechanisms within Plasmodium species disrupting parasite-mediated heme metabolism and inducing cytotoxic free heme accumulation At the molecular level quinoline derivatives may inhibit nucleic acid synthesis affecting DNA replication and transcription events during erythrocytic lifecycle stages Researchers frequently utilize Quinine HCl Dihydrate for studies on antimalarial drug mechanisms parasite resistance pathways and as a reference standard in pharmacological and pharmacokinetic assessments
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