Quinolines and derivatives
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Filtered Search Results
TARGETMOL CHEMICALS INC SCIADOPITYSIN 10MG
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Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Sciadopitysin may prevent the development of diabetic osteopathy it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in osteoblastic MC3T3-E1 cells it may reduce or prevent osteoblasts degeneration.Sciadopitysin can inhibit the A(beta) aggregation and reduce A(beta)-induced toxicity in the primary cortical neurons. purity: 99%
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TARGETMOL CHEMICALS INC MORACIN C 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Moracin C a natural compound found in Morus mesozygia Morus alba var. multicaulis is an anti-inflammatory agent. moracin C inhibits nitric oxide (NO) release and LPS-activated reactive oxygen species (ROS) in cells. purity: 99%
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TARGETMOL CHEMICALS INC FENGABINE 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Fengabine (SL-79229) is a GABA receptor agonist with antidepressant activity and is used to treat depression. purity: 98%
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Medchemexpress LLC 7-Deazaguanine | 7355-55-7 | HY-34222 | 99.73% | 150.14 | 25 G
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7-Deazaguanine (Compound 1) is a highly selective, well-tolerated, brain-penetrant DYRK1A inhibitor. It is promising for research of cancers and Down's syndrome.
- Highly selective DYRK1A inhibitor
- Well-tolerated
- Brain-penetrant
- Promising for research of cancers
- Promising for research of Down's syndrome
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Medchemexpress LLC 7-Hydroxycarbostyril | 70500-72-0 | 99.05% | 161.16 | 25 G
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7-Hydroxycarbostyril (7-Hydroxy-2(1H)-quinolinone) is a quinolinone derivative. This compound is utilized in the synthesis of brexpiprazole, an orally active antipsychotic agent that functions as a partial agonist for both human 5-HT1A and dopamine D2L receptors.
- A quinolinone derivative.
- Used for the synthesis of brexpiprazole.
- High purity: 99.05%.
- For research use only.
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TARGETMOL CHEMICALS INC ZINC12409120 5MG
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 uM.ZINC12409120 inhibits ERK activity by interfering with FGF23(alpha)-Klotho interaction. purity: 99%
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Medchemexpress LLC 1-Methyl-2-pentyl-4(1H)-quinolinone | 22048-98-2 | 229.32 | 5 MG
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1-Methyl-2-pentyl-4(1H)-quinolinone is a quinolone alkaloid isolated from the fruits of Evodia Rutaecarpa. It possesses antibacterial and cytotoxic activities for cancer cells.
- Quinolone alkaloid
- Isolated from the fruits of Evodia Rutaecarpa
- Possesses antibacterial activities
- Exhibits cytotoxic activities for cancer cells
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Medchemexpress LLC 2-(2,6-Dioxopiperidin-3-yl)phthalimidine | 26581-81-7 | 99.7% | 244.25 | 200 MG
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2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12) is a teratogenic Thalidomide analogue that is more active than Thalidomide and is more stable for hydrolysis. It enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas. It is an off-white to gray solid.
- Teratogenic thalidomide analogue
- More active than thalidomide
- More stable to hydrolysis
- Enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas
- Off-white to gray solid
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Medchemexpress LLC Amino-PEG3-C2-sulfonic acid | 1817735-43-5 | 99.47% | 257.30 | 100 MG
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Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, with one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Utilized in the synthesis of PROTACs
- Contains two distinct ligands connected by a linker
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC 4,6(1H,5H)-Pyrimidinedione, 1-(3-chloro-4-methylphenyl)-5-[3-(2-furanyl)-2-propen-1-ylidene] | 593273-05-3 | 99.2% | 372.83 | 25 MG
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DCH36_06 is a potent and selective p300/CBP inhibitor. It mediates p300/CBP inhibition, leading to hypoacetylation on H3K18 in leukemic cells, and exhibits anti-tumor activity.
- Potent and selective p300/CBP inhibitor.
- Induces apoptosis in leukemic cells.
- Arrests cell cycle at G1 phase.
- Shows potent antiproliferative activity against a range of leukemia cell lines.
- Blocks leukemic xenograft growth in mice.
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Medchemexpress LLC B7-H2/ICOSLG protein, cynomolgus | >95.0% | 20 UG
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B7-H2/ICOSLG protein (cynomolgus) is a recombinant extracellular domain of the ICOS ligand produced in HEK293 mammalian cells with a C-terminal His tag. Supplied lyophilized from PBS (pH 7.4), the protein is intended for immunology and receptor-ligand interaction studies and is characterized by low endotoxin and a defined amino acid range (M1-T256).
- Recombinant protein expressed in HEK293 mammalian cells.
- C-terminal His tag for purification and detection.
- Amino acid range M1-T256 corresponding to the extracellular domain.
- Observed molecular weight 50-70 kDa.
- Endotoxin <1 EU/μg (LAL method).
- Lyophilized formulation from PBS, pH 7.4; recommend aliquoting for storage.
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Medchemexpress LLC 31-Norlanostenol | 16910-39-7 | 1 MG
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31-Norlanostenol is a triterpenic compound isolated from the latex of Euphorbia officinarum. It can act as an efficient insect growth regulator on S. frugiperda and Tenebrio molitor. This product is for research use only.
- Triterpenic compound
- Isolated from the latex of Euphorbia officinarum
- Acts as an efficient insect growth regulator on S. frugiperda and Tenebrio molitor
- Purity: 99.94%
- Molecular Weight: 414.71
- Formula: C29H50O
- Appearance: Solid
- Color: White to off-white
- Structure classification: Terpenoids, Triterpenes
- Initial source: Plants, Euphorbiaceae, Euphorbia boetica
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TARGETMOL CHEMICALS INC MK2-IN-1 HYDROCHLORIDE 25MG
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Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MK2-IN-1 hydrochloride (MK 25) is a highly selective non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2 IC50 0.11 uM) [1]. purity: 99%
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TARGETMOL CHEMICALS INC AP 18 5MG
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Also available in 1mg 2mg 10mg 25mg 50mg 100mg 500mg and bulk. Please contact Fisher for quotes. AP-18 is a potent and selective TRPA1 inhibitor. AP-18 inhibits activation of TRPA1 induced by 50 μM Cinnamaldehyde with an IC50 of 3.1 μM and 4.5 μM for human and mouse TRPA1 respectively. AP-18 could reverse complete Freund's adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 could attenuate Yo-Pro uptake induced by 30 μM AITC in a concentration-dependent manner (IC50= 10.3 μM). purity: 99%
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Medchemexpress LLC Benzyl-PEG5-amine | 86770-77-6 | MFCD28976656 | 98.0% | C17H29NO5 | 100 MG
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Benzyl-PEG5-amine is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are compounds characterized by two distinct ligands joined by a linker, where one ligand binds to an E3 ubiquitin ligase and the other to a target protein. This design enables PROTACs to utilize the intracellular ubiquitin-proteasome system to achieve the selective degradation of specific target proteins.
- Functions as a PROTAC linker.
- Supports the synthesis of PROTACs.
- Engages the ubiquitin-proteasome system for protein degradation.
- Enables selective degradation of target proteins.
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